How donors
and patients are matched?
Donors and patients are matched by their HLA type, which is
different from matching blood types. A simple cheek swab can help us determine
whether you’re a close bone marrow match for a patient.
The best
marrow transplant outcomes happen when a patient’s Human Leukocyte
Antigen (HLA) and the HLA of a registry member or cord blood unit closely
match. This is much more complex than matching blood types. HLA is a protein
(or marker) found on most cells in your body. Your immune system uses HLA
markers to know which cells belong in your body and which do not. There are
many HLA markers that make a person’s tissue type unique; however, matching
certain markers is what is critical to a successful transplant.
What makes a close match?
Be The
Match Registry® is a listing of potential donors and cord blood units and their
HLA types. When people join the Be The Match Registry, they provide a sample of
their DNA by swabbing their cheek. This cheek swab is tested for a minimum of 6
basic HLA markers.
A
patient’s doctor will usually choose several donors who appear to match the
patient at a basic level. The doctor will ask that these donors have
additional tests. These detailed tests will show which donor’s HLA most closely
matches the patient’s HLA markers. These tests are usually blood tests or
additional cheek swabs.
About 8%
of members who complete additional testing will go on to donate. If a member is
asked to donate, that means they are the closest HLA match to the patient – the
best donor.
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| Brynnik Johnson and his donor. |
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